穀胱甘肽
穀胱甘肽(GSH)是人體主要抗氧化劑，對健康具有實質的影響。讓我們來瞭解一下RiboCeine™如何幫助人體自然生成穀胱甘肽，並看看這項產品對你我有什麼意義。
醫生的優質推薦
請一起聽聽唐‧科爾伯特醫師及道格拉斯 • 哈林頓醫師介紹穀胱甘肽的重要性及Max International產品如何讓這個重要的營養素改善我們的健康。
https://www.youtube.com/watch?v=sKEmPc-3Rfo
RiboCeine 獨立研究
(Rib-Cys, Ribose-Cysteine, D-Ribose-L-Cysteine)
1. Roberts, J.C.; Nagasawa, H.T.; Zera, R.T.; Fricke, R.F.; Goon, D.J. W. Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(polyhydroxyalky)-and 2-(Polyacetoxyalky)-Thiazolidine-4(R)-Carboxylic Acids. Med. Chem., 1987, 30, 1891-1896.
Roberts JC, Nagasawa HT, Zera RT, Fricke RF, Goon DJW. L-半胱氨酸前驅藥物做為抵抗乙醯氨基酚誘發之肝毒性的保護劑。2-(Polyhydroxyalkyl)- and 2-(Polyacetoxyalkyl) thiazolidine-4(R)-carboxylic Acids. 醫藥化學期刊，1987, 30:1891-1896.
2. Roberts, J.C.; Francetic, D.J.; Zera, R.T. L-cysteine prodrug protects against cyclophosphamide urotoxicity without compromising therapeutic activity. Cancer Chemotherapy and Pharmacology, 1991, 28, 166-170.
Roberts, J.C.; Francetic, D.J.; Zera, R.T. 在未影響治療過程下使用L-半胱氨酸前驅藥來處理癌德星誘發之尿毒的效用。癌症化療與藥理學，1991, 28, 166-170.
3. Roberts, J.C.; Francetic, D.J. Time course for the elevation of glutathione in numerous organs of L1210-bearing CDF1 mice given the L-cysteine prodrug, RibCys. Toxicology Letters, 1991, 59, 245-251.
Roberts, J.C.; Francetic, D.J. 帶L1210細胞之CDF1小鼠施予前驅藥物L-半胱氨酸―RibCys―提升各器官穀胱甘肽濃度之時程。Toxicology Letters期刊，1991, 59, 245-251.
4. Roberts, J.C.; Francetic, D.J. Mechanisms of Chemoprotection by RibCys, a Thiazolidine Prodrug of L-cysteine. Chem. Res., 1991, 1, 213-219.
Roberts, J.C.; Francetic, D.J. RibCys—L-半胱氨酸噻唑烷前驅藥—之化學保護作用機轉。醫學化學研究期刊，1991, 1, 213-219.
5. Roberts, J.C.; Charyulu, R. L.; Zera, R.T.; Nagasawa, H.T. Protection Against Acetaminophen Hepatotoxicity by Ribose-Cysteine (RibCys). Pharmacology & Toxicology, 1992, 70, 281-285.
Roberts, J.C.; Charyulu, R. L.; Zera, R.T.; Nagasawa, H.T. 對乙酰氨基酚誘發之肝毒性使用核醣-半胱氨酸後的保護效用。藥理學與毒物學期刊，1992, 70, 281-285.
6. Rowe, J.K.; Zera, R.T.; Madoff, R.D.; Fink, A.S.; Roberts, J.C.; Johnston, G.R.; Freeney, D.A.;Young, H.L.; Bubrick, M.P. Protective Effect of RibCys Following High-Dose Irradiation of the Rectosigmoid. Colon Rectum, 1993, 36(7), 681-687.
Rowe, J.K.; Zera, R.T.; Madoff, R.D.; Fink, A.S.; Roberts, J.C.; Johnston, G.R.; Freeney, D.A.;Young, H.L.; Bubrick, M.P. 直腸乙狀結腸高劑量輻射後使用RibCys之保護效果。結腸直腸期刊，1993, 36(7), 681-687.
7. Roberts, J.C.; Francetic, D.J.; Zera, R.T. Chemoprotection against Cyclophosphamide-Induced Urotoxicity: Comparison of Nine Thiol Protective Agents. AntiCancer Research, 1994, 14, 389-396.
Roberts, J.C.; Francetic, D.J.; Zera, R.T. 利用化學保護作用對抗癌德星誘發之尿毒：九種硫醇保護劑之比較。抗癌研究期刊，1994, 14, 389-396.
8. Carroll, M.P.; Zera, R.T.; Roberts, J.C.; Schlafmann, S.E.; Feeny, D.A.; Johnston, G.R.; West, M.A.; Bubrick, M.P. Efficacy of radioprotective agents in preventing small and large bowel radiation injury. Colon Rectum, 1995, 38(7), 716-722.
Carroll, M.P.; Zera, R.T.; Roberts, J.C.; Schlafmann, S.E.; Feeny, D.A.; Johnston, G.R.; West, M.A.; Bubrick, M.P. 輻射保護劑對預防小型及大型腸道輻射傷害之效用。結腸直腸期刊，1995, 38(7), 716-722.
9. Roberts, J.C.; Koch, K.E.; Detrick, S.R.; Warters, R.L.; Lubec G. Thiazolidine Prodrugs of Cysteamine and Cysteine as Radioprotective Agents. Radiation Research, 1995, 143, 203-213.
Roberts, J.C.; Koch, K.E.; Detrick, S.R.; Warters, R.L.; Lubec G. 使用半胱胺及半胱氨酸之噻唑烷前驅藥做為輻射保護劑。輻射研究期刊，1995, 143, 203-213.
10. Bantseev, V.; Bhardwaj, R.; Rathbun, W.; Nagasawa, H.T.; Trevithick, J.R. Antioxidants and Cataract: (Cataract Induction in Space Environment and Application to Terrestrial Aging Cataract). Mol. Bio. Intl., 1997, 42, 1189-1197.
Bantseev, V.; Bhardwaj, R.; Rathbun, W.; Nagasawa, H.T.; Trevithick, J.R. 抗氧化劑與白內障：(太空環境誘發之白內障與陸地上老化白內障之應用)。國際生化與分子生物學期刊，1997, 42, 1189-1197.
11. Roberts, J.C.; Phaneuf, H.L.; Szakacs, J.G.; Zera, R.T.; Lamb, J.G.; Franklin, M.R. Differential Chemoprotection against Acetaminophen-Induced Hepatotoxicity by Latentiated L-Cysteines. Res. Toxicol., 1998, 11, 1274-1282.
Roberts, J.C.; Phaneuf, H.L.; Szakacs, J.G.; Zera, R.T.; Lamb, J.G.; Franklin, M.R. 潛伏性L-半胱氨酸處理乙酰氨基酚誘發的肝臟毒性時之不同化學保護作用。毒理學期刊，1998, 11, 1274-1282.
12. Roberts, J.C.; Phaneuf, H.L.; Dominick, P.K.; Wilmore, B.H.; Cassidy, P.B. Biodistribution of [35S] – Cysteine and Cysteine Prodrugs: Potential Impact on Chemoprotection Strategies. Labelled Cpd. Radiopharm., 1999, 42, 485-495.
Roberts, J.C.; Phaneuf, H.L.; Dominick, P.K.; Wilmore, B.H.; Cassidy, P.B. [35S]生物分佈 – 半胱氨酸與半胱氨酸前驅藥：對化學保護作用策略的可能影響。標誌Cpd.核醫藥物期刊，1999, 42, 485-495.
13. Lucus, A.M.; Henning G.; Dominick, P.K.; Whiteley, H.E.; Roberts, J.C.; Cohen, S.D. Ribose Cysteine Protects Against Acetaminophen-Induced Hepatic and Renal Toxicity. Toxicologic Pathology, 2000, 28(5), 697-704.
Lucus, A.M.; Henning G.; Dominick, P.K.; Whiteley, H.E.; Roberts, J.C.; Cohen, S.D. 使用核糖半胱氨酸處理對乙酰氨基酚誘發的肝臟與腎臟毒性。毒物病理學，2000, 28(5), 697-704.
14. Wilmore, B.H.; Cassidy, P.B.; Warters, R.L.; Roberts, J.C. Thiazolidine Prodrugs as Protective Agents against γ-Radiation-Induced Toxicity and Mutagenesis in V79 Cells. Med. Chem., 2001, 44(16), 2661-2666.
Wilmore, B.H.; Cassidy, P.B.; Warters, R.L.; Roberts, J.C. 以噻唑烷前驅藥做為治療V79細胞中y輻射誘發之毒性與突變的保護劑。醫藥化學期刊，2001, 44(16), 2661-2666.
15. Lenarczyk, M.; Ueno, A.; Vannais, D.B.; Kraemer, S.; Kronenberg, A.; Roberts, J.C.; Tatsumi, K.; Hei, T.K.; Waldren, C.A. The “pro-drug” RibCys decreases the mutagenicity of high-LET radiation in cultured mammalian cells. Radiation Research, 2003, 160, 579-583.
Lenarczyk, M.; Ueno, A.; Vannais, D.B.; Kraemer, S.; Kronenberg, A.; Roberts, J.C.; Tatsumi, K.; Hei, T.K.; Waldron, C.A. 前驅藥物RibCys可降低培養哺乳動物細胞中高線性能量轉移(LET)輻射之致突變性。輻射研究期刊，2003, 160, 579-583.
16. Waldren, C.A.; Vannais, D.B.; Ueno A.M. A role for long-lived radicals (LLR) in radiation-induced mutation and persistent chromosomal instability: counteraction by Ascorbate and RibCys but not DMSO. Mutation Research, 2004, 551:255-265.
Waldren, C.A.; Vannais, D.B.; Ueno A.M. 長壽自由基造成輻射性突變與持續性染色體不穩定所扮演的角色：利用抗壞血酸與RibCys等非二甲基亞碸進行的中和作用。突變研究期刊，2004, 551:255-265.
17. Lucas Slitt, A.M.; Dominick, P.K.; Roberts, J.C.; Cohen, S.D. Effect of ribose cysteine pretreatment on hepatic and renal acetaminophen metabolite formation and glutathione depletion. Basic Clin. Pharmacol. Toxicol., 2005, 96 (6), 487-94.
Lucas Slitt, A.M.; Dominick, P.K.; Roberts, J.C.; Cohen, S.D. 核糖半胱氨酸預防性治療對肝腎乙醯氨基酚代謝產物形成及穀胱甘肽減少之影響。基礎與臨床藥理學和毒理學期刊，2005, 96 (6), 487-94.
18. Oz, H.S.; Chen, T.S.; Nagasawa, H., Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model. Translational Research, 2007, 150(2), 122-129.
Oz, H.S.; Chen, T.S.; Nagasawa, H., C結腸炎模式中兩種半胱氨酸前驅藥物與穀胱甘肽輸送媒介物之功效比較。轉譯研究，2007, 150(2), 122-129.
19. Jurkowska, H.; Uchacz, T.; Roberts, J.; Wrobel, M. Potential therapeutic advantage of ribose-cysteine in the inhibition of astrocytoma cell proliferation. Amino Acids, 2011, 41, 131-139.
Jurkowska, H.; Uchacz, T.; Roberts, J.; Wrobel, M. 核醣-半胱氨酸抑制星狀瘤細胞增生之潛在治療優勢。胺基酸期刊，2011, 41, 131-139.
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22. Kader, T.; Porteous C.M.; Williams M.J.A.; Gieseg, S.P.; McCormick, S.P.A. Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice. Atherosclerosis, 2014, 237, 725-733.
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